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1. The new methods of research had been included into my work.

(-) The new methods of research hadn’t been included into my work.

(?) Had the new methods of research been included into your work?

2. The course of treatment has been prolonged.

(-) The course of treatment hasn’t been prolonged.

(?) Has the course of treatment been prolonged?

3. The structure of the pancreas will have been described in the new book.

(-) The structure of the pancreas won’t have been described in the new book.

(?) Will the structure of the pancreas have been described in the new book?

Mary: What do you want to do when you grow up, Fred?

Fred: I’d like to work as a chef in a big hotel.

Mary: Oh no! I’ve worked in a kitchen before. It’s like working in an oven.

Fred: At least it wouldn’t be as boring as working in a bank.

Mary: Don’t you want to be something more interesting, such as a lawyer, or a doctor.

Fred: No, I’d prefer to do something creative like cooking, I could never see myself as a lawyer or a doctor.

Mary: You’re just like my brother. He’s always saying things like that.